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Effect of Pterocarpus erinaceus Stem Bark Extracts on Haematological Parameters in Malaria Induced Anaemic Mice

Received: 24 February 2021     Accepted: 13 March 2021     Published: 16 April 2021
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Abstract

Traditionally Pterocarpus erinaceus stem bark have being widely used in treatment of anemia. The goal of this examination is to explore the viability of Pterocarpus erinaceus stem bark removes on jungle fever initiated paleness. Anaemia was induced by inoculation of 2ml of infected blood containing 0.1 x 107 Plasmodium beghei. The sickly mice were treated with 250 and 500mg/body weight of watery and ethanolic concentrates of Pterocarpus erinaceus stem bark for four days. The results shows that there is significant (P>0.005) increase in both haematological parameters (PCV, Hb and RBC), haematological indices (MCV, MCH and MCHC) and immunological parameters (WBC, platelets, neutrophils and lymphocytes) in malaria control compared to normal. Oral administration of 250 and 500mg/kg body weight of aqueous and ethanolic extract of Pterocarpus erinaceus stem bark shows significant increase (p>0.05) in haematological parameters compared to malaria control. There were significant improvement in WBC, platelets, neutrophils, hympolytes and MCH. Compared to malaria control. The anaemic mice treated with 250/500mg/kg body weight of ethanolic extract showed significant improvement in both haematological and immunological parameters tested. These result suggest that Pterocarpus erinaceus stem bark can he used in managing anemia.

Published in American Journal of Chemical and Biochemical Engineering (Volume 5, Issue 1)
DOI 10.11648/j.ajcbe.20210501.13
Page(s) 21-25
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Pterocarpus erinaceus, Anaemia, Malaria

References
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[2] Umar, T. T., Umar, I. A and Ibrahim, A. (2007), phytochemical analysis and in vitro ant plasmodium activity of Chrozophora senegalensis extract on Plasmodium falciparum. Nig. Journal of chemical research. Vol. 22 (2): 62-71.
[3] Sumbele, I. U. N., Sama S. O., Kimbi, H. K. and Taiwe G. S. (2016). Malaria, Moderate to Severe Anaemia, and Malarial Anaemia in Children at Presentation to Hospital in the Mount Cameroon Area: A Cross-Sectional Study. Anemia Volume 2016, Article ID 5725634, 12 pages.
[4] Suzanne, B. B. S., Adeline, F. Y. S., Theodora, K. K., Dairou, H., Pradel, K. L., Aristide, K. M., Mathieu, N., Gabriel, A. A., Anne, N. N. R. and Clerge, T. (2020). Hemopoietic effects of some herbal extracts used in treatment of infantile anemia in Cameroon. WJPMR, 6 (1), 147-155.
[5] Anjusha, K. V., Mamun, M. A. A., Dharmakar, P. and Shamima, N. (2019). Effect of Medicinal Herbs on Hematology of Fishes. Int. J. Curr. Microbiol. App. Sci 8 (9): 2371-2376.
[6] WHO (2010). In vivo micro-test (Mark -111) for the assessment of the response of plasmodium falciparum to chloroquine, mefloquine, quinine, amodaquine, sulfodoxine/pyrimethamin and artemisinin, instruction for use of the in vitro micro-test kit (mark 111) 2001 ciD/mal/97.20 Rev. 2.
[7] Ryley, J. F. and Peters, W. (1970). The antimalarial activity of some quinolone esters. Ann. Trop. Med. Parasitol. 84: 209-222.
[8] Baker, F. J., Silverton, R. E. and Pallister, C. J. (1998). Baker and Silverston’s: Introduction to Medical Laboratory Technology. 7th Edition. Bounty Press LTD. London 337-338.
[9] Veng-paderson, P., Chapel, S., Schmidt, R. L., Al-Huniti, N. H., Cook, R. T and Widness J. A. (2002), An integrated pharmacodynamics analysis of erythropoietin, reticulocyte, and haemoglobin responses in acute anaemia. Pharm Res. 19 (11): 1630-5.
[10] Beales P. E (1997), Anaemia in malaria control: a practical approach Ann Trop Med. Parasitol. 91: 713-18.
[11] Nadro, M. S. and Modibbo, A. A. (2014). Effect of Pterocarpus erinaceus stem bark aqueous extract on anemic rats. SCIR II (V): 1-5.
[12] Iwalewa E. O, (1995). Evaluation of anti-malerial properties of Cassia occidentalis’ and Azadiracha indica’ leaves. Published PhD thesis Ahmadu Bello University, Zaria, Nigeria.
[13] Okwu, D. E. (2004). Phytochemical and vitamin content of indigenous spices of South Eastern Nigeria. J. Sustain. Agric. Environ. 6: 30-34.
[14] Salahdeen, H. M and Yemitan. K (2006). Neuropharmacologic effects of aqueous leaf extract of Brayophyllum pinnatum Afr. J. Biomed. Res. 9: 101-107.
[15] mMaryam, M. U., Abdullahi, A. M., Moses, Z. Z. and Ismaila, Y. S. (2017). Phytochemical and Nutrient composition of Pterocarpus erinaceus stem bark. Inter. J. of Biochemi. Res. And Rev. 1-6.
[16] Mishra, n. and Tandon, V. L. (2012). Haematological effect of aqueous extract of Ornamental plants in Male Swiss albino rats. Vet. World. 5 (1): 19-23.
[17] Jorum, O. H., Piero, N. M. and Machocho, A. K. (2016). Haematological effects of dichloromethane-methanolic leaf extracts of Carissa edulis (Forssk) vahl in normal rats’ models. J. of Haem. And Thromboembolic Disease. 4: 232-236.
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    Ibrahim Mohammed, Hauwa’u Shuaibu Mohammed, Modibbo Abdullahi Abubakar. (2021). Effect of Pterocarpus erinaceus Stem Bark Extracts on Haematological Parameters in Malaria Induced Anaemic Mice. American Journal of Chemical and Biochemical Engineering, 5(1), 21-25. https://doi.org/10.11648/j.ajcbe.20210501.13

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    ACS Style

    Ibrahim Mohammed; Hauwa’u Shuaibu Mohammed; Modibbo Abdullahi Abubakar. Effect of Pterocarpus erinaceus Stem Bark Extracts on Haematological Parameters in Malaria Induced Anaemic Mice. Am. J. Chem. Biochem. Eng. 2021, 5(1), 21-25. doi: 10.11648/j.ajcbe.20210501.13

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    AMA Style

    Ibrahim Mohammed, Hauwa’u Shuaibu Mohammed, Modibbo Abdullahi Abubakar. Effect of Pterocarpus erinaceus Stem Bark Extracts on Haematological Parameters in Malaria Induced Anaemic Mice. Am J Chem Biochem Eng. 2021;5(1):21-25. doi: 10.11648/j.ajcbe.20210501.13

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  • @article{10.11648/j.ajcbe.20210501.13,
      author = {Ibrahim Mohammed and Hauwa’u Shuaibu Mohammed and Modibbo Abdullahi Abubakar},
      title = {Effect of Pterocarpus erinaceus Stem Bark Extracts on Haematological Parameters in Malaria Induced Anaemic Mice},
      journal = {American Journal of Chemical and Biochemical Engineering},
      volume = {5},
      number = {1},
      pages = {21-25},
      doi = {10.11648/j.ajcbe.20210501.13},
      url = {https://doi.org/10.11648/j.ajcbe.20210501.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcbe.20210501.13},
      abstract = {Traditionally Pterocarpus erinaceus stem bark have being widely used in treatment of anemia. The goal of this examination is to explore the viability of Pterocarpus erinaceus stem bark removes on jungle fever initiated paleness. Anaemia was induced by inoculation of 2ml of infected blood containing 0.1 x 107 Plasmodium beghei. The sickly mice were treated with 250 and 500mg/body weight of watery and ethanolic concentrates of Pterocarpus erinaceus stem bark for four days. The results shows that there is significant (P>0.005) increase in both haematological parameters (PCV, Hb and RBC), haematological indices (MCV, MCH and MCHC) and immunological parameters (WBC, platelets, neutrophils and lymphocytes) in malaria control compared to normal. Oral administration of 250 and 500mg/kg body weight of aqueous and ethanolic extract of Pterocarpus erinaceus stem bark shows significant increase (p>0.05) in haematological parameters compared to malaria control. There were significant improvement in WBC, platelets, neutrophils, hympolytes and MCH. Compared to malaria control. The anaemic mice treated with 250/500mg/kg body weight of ethanolic extract showed significant improvement in both haematological and immunological parameters tested. These result suggest that Pterocarpus erinaceus stem bark can he used in managing anemia.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Effect of Pterocarpus erinaceus Stem Bark Extracts on Haematological Parameters in Malaria Induced Anaemic Mice
    AU  - Ibrahim Mohammed
    AU  - Hauwa’u Shuaibu Mohammed
    AU  - Modibbo Abdullahi Abubakar
    Y1  - 2021/04/16
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajcbe.20210501.13
    DO  - 10.11648/j.ajcbe.20210501.13
    T2  - American Journal of Chemical and Biochemical Engineering
    JF  - American Journal of Chemical and Biochemical Engineering
    JO  - American Journal of Chemical and Biochemical Engineering
    SP  - 21
    EP  - 25
    PB  - Science Publishing Group
    SN  - 2639-9989
    UR  - https://doi.org/10.11648/j.ajcbe.20210501.13
    AB  - Traditionally Pterocarpus erinaceus stem bark have being widely used in treatment of anemia. The goal of this examination is to explore the viability of Pterocarpus erinaceus stem bark removes on jungle fever initiated paleness. Anaemia was induced by inoculation of 2ml of infected blood containing 0.1 x 107 Plasmodium beghei. The sickly mice were treated with 250 and 500mg/body weight of watery and ethanolic concentrates of Pterocarpus erinaceus stem bark for four days. The results shows that there is significant (P>0.005) increase in both haematological parameters (PCV, Hb and RBC), haematological indices (MCV, MCH and MCHC) and immunological parameters (WBC, platelets, neutrophils and lymphocytes) in malaria control compared to normal. Oral administration of 250 and 500mg/kg body weight of aqueous and ethanolic extract of Pterocarpus erinaceus stem bark shows significant increase (p>0.05) in haematological parameters compared to malaria control. There were significant improvement in WBC, platelets, neutrophils, hympolytes and MCH. Compared to malaria control. The anaemic mice treated with 250/500mg/kg body weight of ethanolic extract showed significant improvement in both haematological and immunological parameters tested. These result suggest that Pterocarpus erinaceus stem bark can he used in managing anemia.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Chemical Science Technology Department, Federal Polytechnic, Mubi, Nigeria

  • Chemical Science Technology Department, Federal Polytechnic, Mubi, Nigeria

  • Chemical Science Technology Department, Federal Polytechnic, Mubi, Nigeria

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